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Using RNA aptamers to quantify TDP-43 proteoforms

Aptamer-based enrichment coupled to an MRM method enabled quantification of TDP-43 and identification of C-terminal fragments


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Aptamer-based enrichment of TDP-43 from human cells and tissues with quantification by HPLC-MS/MS.

Pobran TD, Yang D, Mackenzie IRA, DeMarco ML. Journal of Neuroscience Methods, Special edition: Methods and Models for Detection, Monitoring and Intervention of Neurological Disorders. 2021;363:109344.